Lisinopril

Life Flow One
The Solution For Heart Disease

by
Karl Loren

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Reference Number One

 

Reference Number Two

 

---

 

Number One

lisinopril

Tradename Prinivil | Zestril

Manufacturer Merck | Zeneca

Treatment Class Cardiovascular

Indication Hypertension/chronic heart failure

MSB Review: Focus On... Cardiology

MSB Review: Focus On... ACE Inhibitors in the 90s

MSB Review: Focus On... Congestive Heart Failure

ASH96 EHLB: Head-to-head heart drug study designed to settle treatment controversy

DrugFAQ: Zestril Frequently-Asked Questions

FDA Consumer: Lessening the Pressure: Array of Drugs Tames Hypertension- Jul 99 

Reference Number Two

ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS
(Systemic)

ACE inhibitors belong to the class of medicines called high blood pressure medicines (antihypertensives). They are used to treat high blood pressure (hypertension).

High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Captopril is used in some patients after a heart attack. After a heart attack, some of the heart muscle is damaged and weakened. The heart muscle may continue to weaken as time goes by. This makes it more difficult for the heart to pump blood. Captopril helps slow down the further weakening of the heart.

Captopril is also used to treat kidney problems in some diabetic patients who use insulin to control their diabetes. Over time, these kidney problems may get worse. Captopril may help slow down the further worsening of kidney problems.

In addition, some ACE inhibitors are used to treat congestive heart failure, or may be used for other conditions as determined by your doctor.

The exact way that these medicines work is not known. They block an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, they relax blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

These medicines are available only with your doctor's prescription, in the following dosage forms:

Oral

Benazepril

Tablets (U.S.)

Captopril

• Tablets (U.S. and Canada)

  Enalapril

• Tablets (U.S. and Canada)

  Fosinopril

• Tablets (U.S.)

  Lisinopril

• Tablets (U.S. and Canada)

  Quinapril

• Tablets (U.S.)

  Ramipril

   

• Capsules (U.S.)

  Parenteral

  Enalaprilat

   

• Injection (U.S. and Canada)

   

  ---

  Before Using This Medicine

  In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For the angiotensin-converting enzyme (ACE) inhibitors, the following should be considered:

  Allergies
  -- Tell your doctor if you have ever had any unusual or allergic reaction to benazepril, captopril, enalapril, fosinopril, lisinopril, quinapril, or ramipril. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

  Pregnancy
  -- Use of angiotensin-converting enzyme (ACE) inhibitors during pregnancy, especially in the second and third trimesters (after the first three months) can cause low blood pressure, severe kidney failure, too much potassium, or even death in the newborn. Therefore, it is important that you check with your doctor immediately if you think that you may be pregnant. Be sure that you have discussed this with your doctor before taking this medicine. In addition, if you are taking:

   

• Benazepril -- Benazepril has not been shown to cause birth defects in animals when given in doses more than 3 times the highest recommended human dose.

   

• Captopril -- Studies in rabbits and rats at doses up to 400 times the recommended human dose have shown that captopril causes an increase in deaths of the fetus and newborn. Also, captopril has caused deformed skulls in the offspring of rabbits given doses 2 to 70 times the recommended human dose.

   

• Enalapril -- Studies in rats at doses many times the recommended human dose have shown that use of enalapril causes the fetus to be smaller than normal. Studies in rabbits have shown that enalapril causes an increase in fetal death. Enalapril has not been shown to cause birth defects in rats or rabbits.

   

• Fosinopril -- Studies in rats have shown that fosinopril causes the fetus to be smaller than normal. Studies in rabbits have shown that fosinopril causes fetal death, probably due to extremely low blood pressure. In rats, birth defects such as skeletal and facial deformities were seen. However, it is not clear that the deformities were related to fosinopril. Birth defects were not seen in rabbits.

   

• Lisinopril -- Studies in mice and rats at doses many times the recommended human dose have shown that use of lisinopril causes a decrease in successful pregnancies, a decrease in the weight of infants, and an increase in infant deaths. It has also caused a decrease in successful pregnancies and abnormal bone growth in rabbits. Lisinopril has not been shown to cause birth defects in mice, rats, or rabbits.

   

• Quinapril -- Studies in rats have shown that quinapril causes lower birth weights and changes in kidney structure of the fetus. However, birth defects were not seen in rabbits given quinapril.

   

• Ramipril -- Studies in animals have shown that ramipril causes lower birth weights.

  Breast-feeding
  --

   

• Benazepril, captopril, and fosinopril -- These medicines pass into breast milk.

   

• Enalapril, lisinopril, quinapril, or ramipril -- It is not known whether these medicines pass into breast milk. However, these medicines have not been reported to cause problems in nursing babies.

  Children
  -- Children may be especially sensitive to the blood pressure-lowering effect of ACE inhibitors. This may increase the chance of side effects or other problems during treatment. Therefore, it is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.

  Older adults
  -- This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

  Other medicines
  -- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking or receiving ACE inhibitors it is especially important that your health care professional know if you are taking any of the following:

   

• Diuretics (water pills) -- Effects on blood pressure may be increased. In addition, some diuretics make the increase in potassium in the blood caused by ACE inhibitors even greater

   

• Potassium-containing medicines or supplements or

   

• Salt substitutes or

   

• Low-salt milk -- Use of these substances with ACE inhibitors may result in an unusually high potassium level in the blood, which can lead to heart rhythm and other problems

  Other medical problems
  -- The presence of other medical problems may affect the use of the ACE inhibitors. Make sure you tell your doctor if you have any other medical problems, especially:

   

• Diabetes mellitus (sugar diabetes) -- Increased risk of potassium levels in the body becoming too high

   

• Heart or blood vessel disease or

   

• Heart attack or stroke (recent) -- Lowering blood pressure may make problems resulting from these conditions worse

   

• Kidney disease or

   

• Liver disease -- Effects may be increased because of slower removal of medicine from the body

   

• Kidney transplant -- Increased risk of kidney disease caused by ACE inhibitors

   

• Systemic lupus erythematosus (SLE) -- Increased risk of blood problems caused by ACE inhibitors

   

• Previous reaction to any ACE inhibitor involving hoarseness; swelling of face, mouth, hands, or feet; or sudden trouble in breathing -- Reaction is more likely to occur again

   

  ---

  Proper Use of This Medicine

  To help you remember to take your medicine, try to get into the habit of taking it at the same time each day.

  For patients taking captopril:

   

• This medicine is best taken on an empty stomach 1 hour before meals, unless you are otherwise directed by your doctor.

  For patients taking this medicine for high blood pressure:

   

• In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and care in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

   

• Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

   

• Remember that this medicine will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

  Dosing
  -- The dose of the ACE inhibitor will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses. If your dose is different, do not change it unless your doctor tells you to do so.

  The number of capsules or tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking the ACE inhibitor.

  For benazepril

   

• For oral dosage form (tablets):

  -- For high blood pressure:

   

• Adults -- 10 milligrams (mg) once a day at first. Then, your doctor may increase your dose to 20 to 40 mg a day taken as a single dose or divided into two doses.

   

• Children -- Use and dose must be determined by your doctor.

  For captopril

   

• For oral dosage form (tablets):

  -- For congestive heart failure:

   

• Adults -- 12.5 to 100 mg two or three times a day.

   

• Children -- Dose must be determined by your doctor.

  -- For high blood pressure:

   

• Adults -- 12.5 to 25 mg two or three times a day.

   

• Children -- Dose must be determined by your doctor.

  -- For kidney problems related to diabetes:

   

• Adults -- 25 mg three times a day.

  -- For treatment after a heart attack:

   

• Adults -- 12.5 to 50 mg three times a day.

  For enalapril

   

• For oral dosage form (tablets):

  -- For congestive heart failure:

   

• Adults -- 2.5 mg once a day or two times a day at first. Your doctor may increase your dose to 5 to 20 mg a day taken as a single dose or divided into two doses.

   

• Children -- Use and dose must be determined by your doctor.

  -- For high blood pressure:

   

• Adults -- 5 mg once a day at first. Then, your doctor may increase your dose to 10 to 40 mg a day taken as a single dose or divided into two doses.

   

• Children -- Use and dose must be determined by your doctor.

  -- For treating weakened heart muscle:

   

• Adults -- 2.5 mg two times a day at first. Then, your doctor may increase your dose up to 20 mg a day taken in divided doses.

   

• For injection dosage form:

  -- For high blood pressure:

   

• Adults -- 1.25 mg every six hours injected into a vein.

   

• Children -- Use and dose must be determined by your doctor.

  For fosinopril

   

• For oral dosage form (tablets):

  -- For high blood pressure:

   

• Adults -- 10 to 40 mg once a day.

   

• Children -- Use and dose must be determined by your doctor.

  For lisinopril

   

• For oral dosage form (tablets):

  -- For congestive heart failure:

   

• Adults -- 2.5 to 20 mg once a day.

   

• Children -- Use and dose must be determined by your doctor.

  -- For high blood pressure:

   

• Adults -- 10 to 40 mg once a day.

   

• Children -- Use and dose must be determined by your doctor.

  For quinapril

   

• For oral dosage form (tablets):

  -- For high blood pressure:

   

• Adults -- 10 mg once a day at first. Then, your doctor may increase your dose to 20 to 80 mg a day taken as a single dose or divided into two doses.

   

• Children -- Use and dose must be determined by your doctor.

  For ramipril

   

• For oral dosage form (capsules):

  -- For high blood pressure:

   

• Adults -- 2.5 mg once a day at first. Then, your doctor may increase your dose up to 20 mg a day taken as a single dose or divided into two doses.

   

• Children -- Use and dose must be determined by your doctor.

  Missed dose
  -- If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  Storage
  -- To store this medicine:

• Keep out of the reach of children.

   

• Store away from heat and direct light.

   

• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.

   

• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

   

  ---

  Precautions While Using This Medicine

  It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

  For patients taking this medicine for high blood pressure:

   

• Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

  Dizziness or lightheadedness may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.

  Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea and vomiting or diarrhea. These conditions may cause you to lose too much water and lead to low blood pressure.

  Dizziness, lightheadedness, or fainting may also occur if you exercise or if the weather is hot. Heavy sweating can cause loss of too much water and low blood pressure. Use extra care during exercise or hot weather.

  Avoid alcoholic beverages until you have discussed their use with your doctor. Alcohol may make the low blood pressure effect worse and/or increase the possibility of dizziness or fainting.

  Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

  For patients taking captopril or fosinopril:

   

• Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

   

  ---

  Side Effects of This Medicine

  Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

  Check with your doctor immediately if any of the following side effects occur:

  Rare

  Fever and chills; hoarseness; swelling of face, mouth, hands, or feet; trouble in swallowing or breathing (sudden); stomach pain, itching of skin, or yellow eyes or skin

  Check with your doctor as soon as possible if any of the following side effects occur:

  Less common

  Dizziness, lightheadedness, or fainting; skin rash, with or without itching, fever, or joint pain

  Rare

  Abdominal pain, abdominal distention, fever, nausea, or vomiting; chest pain

  Signs and symptoms of too much potassium in the body

  Confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs

  Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

  More common

  Cough (dry, continuing)

  Less common

  Diarrhea; headache; loss of taste; nausea; unusual tiredness

  Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

  Additional Information

  Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, ACE inhibitors are used in certain patients with the following medical conditions:

   

• Hypertension in scleroderma (high blood pressure in patients with hardening and thickening of the skin)

   

• Renal crisis in scleroderma (kidney problems in patients with hardening and thickening of the skin)

  Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.

   

  ---

  Some commonly used brand names are

  In the U.S. --

  Accupril (Quinapril (KWIN-a-pril) (Not commercially available in Canada.))

  Altace (Ramipril (ra-MI-pril) (Not commercially available in Canada.))

  Capoten (Captopril (KAP-toe-pril))

  Lotensin (Benazepril (ben-AY-ze-pril) (Not commercially available in Canada.))

  Monopril (Fosinopril (foe-SIN-oh-pril) (Not commercially available in Canada.))

  Prinivil (Lisinopril (lyse-IN-oh-pril))

  Vasotec (Enalapril (e-NAL-a-pril)) (Enalaprilat (e-NAL-a-pril-at))

  Zestril (Lisinopril (lyse-IN-oh-pril))
  

  In Canada --

  Capoten (Captopril (KAP-toe-pril))

  Prinivil (Lisinopril (lyse-IN-oh-pril))

  Vasotec (Enalapril (e-NAL-a-pril)) (Enalaprilat (e-NAL-a-pril-at))

  Zestril (Lisinopril (lyse-IN-oh-pril))
  

  From:USP Drug Information: Advice for the Patient
  

  Copyright © May 20, 2008 6:26 AM by Karl Loren on behalf of Vibrant Life, ALL RIGHTS RESERVED.  Permission is granted for non-commercial downloading, copying, distribution or redistribution on two conditions:  One, that some form of copyright notice is included in every copy distributed or copied, showing the copyright belonging to Vibrant Life, Burbank, CA, at www.oralchelation.com . The second condition is that the material is not to be used for any purpose contrary to the purposes and objectives of this site.  This permission does not extend to materials on this site which are copyrighted by others.

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Copyright © May 20, 2008 6:26 AM by Karl Loren on behalf of Vibrant Life, ALL RIGHTS RESERVED.  Permission is granted for non-commercial downloading, copying, distribution or redistribution on two conditions:  One, that some form of copyright notice is included in every copy distributed or copied, showing the copyright belonging to Vibrant Life, Burbank, CA, at www.oralchelation.com . The second condition is that the material is not to be used for any purpose contrary to the purposes and objectives of this site.  This permission does not extend to materials on this site which are copyrighted by others.

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You can reach Vibrant Life in many ways, including by mail to Vibrant Life, 2808 N. Naomi St., Burbank, CA 91504.  Within the US and Canada, use the toll free number:  (800) 523-4521, the local number:  (818) 558-1799, the FAX:  (818) 558-7299, eMail to kimberly@oralchelation.com or any one of the hundreds of message forms throughout the 50 web sites.  Vibrant Life normally ships the same day we get an order.  There are message forms on each of the 100,000+ pages on this and other sites where you can communicate with Vibrant Life.  Check out our companion site, at:  http://www.oralchelation.net where Karl's 2000 page book is published.  Karl Loren is the author and webmaster for this BOOK, as well as for another web site about ORAL CHELATION.  His personal philosophical articles are at PHILOSOPHY. 

Copyright © May 20, 2008 6:26 AM by Karl Loren on behalf of Vibrant Life, ALL RIGHTS RESERVED.  Permission is granted for non-commercial downloading, copying, distribution or redistribution on two conditions:  One, that some form of copyright notice is included in every copy distributed or copied, showing the copyright belonging to Vibrant Life, Burbank, CA, at www.oralchelation.com . The second condition is that the material is not to be used for any purpose contrary to the purposes and objectives of this site.  This permission does not extend to materials on this site which are copyrighted by others.